Recent progress in the discovery of inhibitors targeting coronavirus proteases
Identifieur interne : 000F54 ( Main/Exploration ); précédent : 000F53; suivant : 000F55Recent progress in the discovery of inhibitors targeting coronavirus proteases
Auteurs : Haofeng Wang ; Song Xue ; Haitao Yang ; Cheng ChenSource :
- Virologica Sinica [ 1674-0769 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (pharmacologie), Coronavirus (enzymologie), Découverte de médicament, Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Inhibiteurs de protéases (), Inhibiteurs de protéases (pharmacologie), Peptide hydrolases (métabolisme), Réplication virale ().
- MESH :
- enzymologie : Coronavirus.
- métabolisme : Peptide hydrolases.
- pharmacologie : Antiviraux, Inhibiteurs de protéases.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Infections à coronavirus.
- Animaux, Antiviraux, Découverte de médicament, Humains, Inhibiteurs de protéases, Réplication virale.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Coronavirus (enzymology), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Drug Discovery, Humans, Peptide Hydrolases (metabolism), Protease Inhibitors (chemistry), Protease Inhibitors (pharmacology), Virus Replication (drug effects).
- MESH :
- chemical , chemistry : Antiviral Agents, Protease Inhibitors.
- chemical , metabolism : Peptide Hydrolases.
- chemical , pharmacology : Antiviral Agents, Protease Inhibitors.
- drug effects : Virus Replication.
- drug therapy : Coronavirus Infections.
- enzymology : Coronavirus.
- virology : Coronavirus Infections.
- Animals, Drug Discovery, Humans.
Abstract
Coronaviruses (CoVs) can cause highly prevalent diseases in humans and animals. The fatal outbreak of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) highlights the threat posed by this unique virus subfamily. However, no specific drugs have been approved to treat CoV-associated diseases to date. The CoV proteases, which play pivotal roles in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, are attractive targets for drug design. This review summarizes the recent advances in biological and structural studies, together with the development of inhibitors targeting CoV proteases, particularly main proteases (Mpros), which could help develop effective treatments to prevent CoV infection.
Url:
DOI: 10.1007/s12250-015-3711-3
PubMed: 26920707
PubMed Central: 7090653
Affiliations:
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Le document en format XML
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The fatal outbreak of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) highlights the threat posed by this unique virus subfamily. However, no specific drugs have been approved to treat CoV-associated diseases to date. The CoV proteases, which play pivotal roles in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, are attractive targets for drug design. This review summarizes the recent advances in biological and structural studies, together with the development of inhibitors targeting CoV proteases, particularly main proteases (M<sup>pro</sup>s), which could help develop effective treatments to prevent CoV infection.<graphic position="anchor" xlink:href="12250_2015_3711_Figa_HTML" id="d29e201"></graphic></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adedeji, Ao" uniqKey="Adedeji A">AO Adedeji</name></author><author><name sortKey="Sarafianos, Sg" uniqKey="Sarafianos S">SG Sarafianos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K Anand</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P Wadhwani</name></author><author><name sortKey="Mesters, Jr" uniqKey="Mesters J">JR Mesters</name></author><author><name 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Liu</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Wei, P" uniqKey="Wei P">P Wei</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Pei, J" uniqKey="Pei J">J Pei</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Lai, L" uniqKey="Lai L">L Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chen, Cheng" sort="Chen, Cheng" uniqKey="Chen C" first="Cheng" last="Chen">Cheng Chen</name><name sortKey="Wang, Haofeng" sort="Wang, Haofeng" uniqKey="Wang H" first="Haofeng" last="Wang">Haofeng Wang</name><name sortKey="Xue, Song" sort="Xue, Song" uniqKey="Xue S" first="Song" last="Xue">Song Xue</name><name sortKey="Yang, Haitao" sort="Yang, Haitao" uniqKey="Yang H" first="Haitao" last="Yang">Haitao Yang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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